Djibril Sidibe is set to be favoured ahead of Seamus Coleman at right-back, while Michael Keane and Yeri Mina are likely to play at centre-back, with Lucas Digne at left-back.
Ferguson caused controversy at Old Trafford as he hauled off Moise Kean after just 18 minutes on the pitch.
The boss insisted it was a tactical decision, but the striker was certainly upset with the move. As a result, he is unlikely to start today.
Everton predicted line-up vs Arsenal – Premier League
(4-4-2) Pickford; Digne, Keane, Mina, Sidibe; Iwobi, Davies, Bernard, Sigurdsson; Calvert-Lewin, Richarlison.